The Journal. The Journal.

The Cancer Vaccine That Could Save Moderna

Aug 28, 2026 · 25m

Summary

Moderna’s stock plummeted 90% as COVID vaccine sales faded, but a breakthrough melanoma vaccine trial has revived the biotech giant. Partnering with Merck, Moderna’s mRNA therapy showed promise in preventing cancer recurrence, marking a pivotal shift from infectious diseases to oncology. This success validates years of risky investment and positions Moderna as a leading player in personalized cancer treatment, potentially transforming its financial future.

Topics discussed

Moderna's stock crash and surprising cancer vaccine breakthrough Sponsors: Harvey AI and Indeed Sponsored Jobs Moderna's origins and early hesitation to target cancer Internal debate: Realists vs. Dreamers on oncology A $500k donation kickstarts the cancer vaccine program Partnership with Merck and the start of clinical trials COVID-19 pandemic derails cancer research but brings wealth Post-pandemic struggles and promising Phase 2 results Phase 3 success and emotional celebration at Moderna FDA approval hopes and future of mRNA oncology New show 'My Monday Morning' and episode credits
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