Radiolab Radiolab

Patient Zero

Aug 21, 2026 · 51m

Summary

This Radiolab episode explores the concept of "Patient Zero" through three distinct narratives. It begins with Typhoid Mary, the first documented healthy carrier of typhoid fever, and her controversial quarantine. The show then debunks the myth of Gaëtan Dugas as the origin of the AIDS epidemic, tracing HIV’s true roots to a chimpanzee spillover in Cameroon around 1908. Finally, it investigates the invention of the high-five, contrasting a fabricated college athlete story with the tragic life of Glenn Burke, the gay baseball player who likely popularized the gesture.

Topics discussed

Intro and sponsors The mystery of Typhoid Mary's origins George Soper hunts down Mary Mallon Mary's isolation on North Brother Island Mary's final years and death Patient Zero: The myth of Gaëtan Dugas Tracing HIV's origins to 1908 The cut hunter and the leap to humans HIV transmission and sponsors The viral story of Lamont Slezyngia Glenn Burke and the 1977 Dodgers high five Debunking the Murray State high five myth Other claims to the high five's invention Conclusion and credits
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