This NPR News episode covers Iran’s defiant response to new U.S. sanctions, with its security chief warning of retaliation against allied nations. Domestically, President Trump launched the Freedom 250 IndyCar race in Washington, while a human-caused wildfire threatens Reno and Tropical Storm Moke hits Hawaii. The broadcast also reports on rising alcohol-related deaths among older adults, declining drinking rates among youth, and new federal guidance on using AI in education.