Huberman Lab Huberman Lab

Essentials: Control Your Brain Chemistry for Focus, Motivation & Well-Being

Aug 6, 2026 · 34m

Summary

Andrew Huberman explains how to optimize brain chemistry by leveraging dopamine, epinephrine, serotonin, and acetylcholine. He details how these neuromodulators fluctuate throughout the day and offers science-based tools to influence them. Strategies include morning sunlight and cold exposure for dopamine, exercise and breathing for epinephrine, choline-rich foods for acetylcholine, and gratitude or myo-inositol for serotonin.

Topics discussed

Introduction to neuromodulators and daily baseline cycles Hormonal interactions with dopamine, epinephrine, and serotonin Sponsor: Eight Sleep mattress covers for temperature regulation Functions of dopamine, epinephrine, serotonin, and acetylcholine Increasing dopamine via sunlight exposure and caffeine Supplements for acute dopamine increases: Tyrosine and PEA Deliberate cold exposure as a potent dopamine tool Sponsor: AG1 Pro nutritional supplement Tools to increase epinephrine: Exercise, caffeine, and breathing Optimizing acetylcholine for focus via diet and supplements Sponsor: Roka Red Lens glasses for evening light filtering Boosting serotonin through gratitude, touch, and myo-inositol
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